Systems biology approach discovers comorbidity interaction of Parkinson's disease with psychiatric disorders utilizing brain transcriptome

Frontiers in Molecular Neuroscience

Molecular Neuroscience

Mohammad Ali Moni¹  Shauli Sarmin Sumi²  Md Asif Nashiry³  Salem A. Alyami⁴ 

[1] Artificial Intelligence and Data Science, Faculty of Health and Behavioural Sciences, School of Health and Rehabilitation Sciences, The University of Queensland, Saint Lucia, QLD, Australia;Artificial Intelligence and Cyber Futures Institute, Charles Stuart University, Bathurst, NSW, Australia;Computer Science and Engineering, Jashore University of Science and Technology, Jashore, Bangladesh;Data Analytics, Northern Alberta Institute of Technology, Edmonton, AB, Canada;Mathematics and Statistics, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia;

关键词: Parkinson's disease;    psychiatric disorder;    bipolar disorder;    schizophrenia;    differentially expressed genes;   

DOI  :  10.3389/fnmol.2023.1232805

 received in 2023-06-01, accepted in 2023-07-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Several studies found that most patients with Parkinson's disorder (PD) appear to have psychiatric symptoms such as depression, anxiety, hallucination, delusion, and cognitive dysfunction. Therefore, recognizing these psychiatrically symptoms of PD patients is crucial for both symptomatic therapy and better knowledge of the pathophysiology of PD. In order to address this issue, we created a bioinformatics framework to determine the effects of PD mRNA expression on understanding its relationship with psychiatric symptoms in PD patients. We have discovered a significant overlap between the sets of differentially expressed genes from PD exposed tissue and psychiatric disordered tissues using RNA-seq datasets. We have chosen Bipolar disorder and Schizophrenia as psychiatric disorders in our study. A number of significant correlations between PD and the occurrence of psychiatric diseases were also found by gene set enrichment analysis, investigations of the protein-protein interaction network, gene regulatory network, and protein-chemical agent interaction network. We anticipate that the results of this pathogenetic study will provide crucial information for understanding the intricate relationship between PD and psychiatric diseases.

【 授权许可】

Unknown   
Copyright © 2023 Nashiry, Sumi, Alyami and Moni.