The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development

Frontiers in Cellular Neuroscience

Cellular Neuroscience

Katherine R. Long¹  Wieland B. Huttner² 

[1] Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom;MRC Centre for Neurodevelopmental Disorders, King’s College London, London, United Kingdom;Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany;

关键词: extracelluar matrix;    human;    neocortex;    development;    neural progenitor;   

DOI  :  10.3389/fncel.2021.804649

 received in 2021-10-29, accepted in 2021-12-20,  发布年份 2022

来源: Frontiers

【 摘 要 】

Extracellular matrix (ECM) has long been known to regulate many aspects of neural development in many different species. However, the role of the ECM in the development of the human neocortex is not yet fully understood. In this review we discuss the role of the ECM in human neocortex development and the different model systems that can be used to investigate this. In particular, we will focus on how the ECM regulates human neural stem and progenitor cell proliferation and differentiation, how the ECM regulates the architecture of the developing human neocortex and the effect of mutations in ECM and ECM-associated genes in neurodevelopmental disorders.

【 授权许可】

Unknown   
Copyright © 2022 Long and Huttner.