Feeding the gut microbiome: impact on multiple sclerosis

Frontiers in Immunology

Immunology

Matteo Bronzini¹  Rachele Rosso¹  Alessandro Maglione¹  Simona Rolla¹  Marinella Clerico²  Federica Masuzzo³  Manuela Matta³ 

[1] Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy;Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy;San Luigi Gonzaga University Hospital, Orbassano, Italy;San Luigi Gonzaga University Hospital, Orbassano, Italy;

关键词: multiple sclerosis;    diet;    gut microbiota;    immune system;    probiotics;    prebiotics;    postbiotics;   

DOI  :  10.3389/fimmu.2023.1176016

 received in 2023-02-28, accepted in 2023-05-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Multiple sclerosis (MS) is a multifactorial neurological disease characterized by chronic inflammation and immune-driven demyelination of the central nervous system (CNS). The rising number of MS cases in the last decade could be partially attributed to environmental changes, among which the alteration of the gut microbiome driven by novel dietary habits is now of particular interest. The intent of this review is to describe how diet can impact the development and course of MS by feeding the gut microbiome. We discuss the role of nutrition and the gut microbiota in MS disease, describing preclinical studies on experimental autoimmune encephalomyelitis (EAE) and clinical studies on dietary interventions in MS, with particular attention to gut metabolites–immune system interactions. Possible tools that target the gut microbiome in MS, such as the use of probiotics, prebiotics and postbiotics, are analyzed as well. Finally, we discuss the open questions and the prospects of these microbiome-targeted therapies for people with MS and for future research.

【 授权许可】

Unknown   
Copyright © 2023 Bronzini, Maglione, Rosso, Matta, Masuzzo, Rolla and Clerico