Strain-level immunomodulatory variation of gut bacteria

FEBS Letters

article

Haitham Hajjo¹  Naama Geva-Zatorsky¹ 

[1] Department of Cell Biology and Cancer Science, Rappaport Technion Integrated Cancer Center ,(TICC), Rappaport Faculty of Medicine, Technion – Israel Institute of Technology;Department of Immunology, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology;Department of Neuroscience, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology;Canadian Institute for Advanced Research ,(CIFAR) Azrieli Global Scholar, MaRS Centre

关键词: bacterial strains;    colon;    gut microbiota;    immune system;    immunomodulatory bacteria;    systemic immunity;   

DOI  :  10.1002/1873-3468.14057

来源: John Wiley & Sons Ltd.

【 摘 要 】

The gut microbiota and the immune system have co-evolved to interact and cooperate in many ways. A recent study characterizing the immunomodulatory effects of over 60 different human-derived gut microbes across phyla showed that bacteria-induced immunomodulations are not dictated by the bacterial phylogeny. Yet, it remains unclear whether strains from the same species induce the same immunomodulatory effects on the host. We analyzed the strain-level data from this recent study and found that strains from the same species can induce distinct and sometimes even opposing immunophenotypes. Hence, we suggest that the immunomodulatory capabilities of gut bacteria can be strain-specific.

【 授权许可】

Unknown