Antibacterial, injectable, and adhesive hydrogel promotes skin healing

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Xing Qiu¹  Qingming Shi²  Wenbing Wan²  Tao Lin³  Fanrong Ai⁴  Yang Feng⁵  Jianqiu Yang⁵  Ziqing Zhong⁵  Ganghua Yang⁵  Guoqing Zhang⁵  Shuai Fan⁵  Zilong Fang⁵ 

[1] Department of Orthopedic Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China;Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision & Brain Health), Wenzhou, Zhejiang, China;School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi, China;The Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi, China;

关键词: antibacterial;    injectable;    promoting healing;    hydrogel;    wound dressing;   

DOI  :  10.3389/fbioe.2023.1180073

 received in 2023-03-05, accepted in 2023-05-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

With the development of material science, hydrogels with antibacterial and wound healing properties are becoming common. However, injectable hydrogels with simple synthetic methods, low cost, inherent antibacterial properties, and inherent promoting fibroblast growth are rare. In this paper, a novel injectable hydrogel wound dressing based on carboxymethyl chitosan (CMCS) and polyethylenimine (PEI) was discovered and constructed. Since CMCS is rich in -OH and -COOH and PEI is rich in -NH2, the two can interact through strong hydrogen bonds, and it is theoretically feasible to form a gel. By changing their ratio, a series of hydrogels can be obtained by stirring and mixing with 5 wt% CMCS aqueous solution and 5 wt% PEI aqueous solution at volume ratios of 7:3, 5:5, and 3:7. Characterized by morphology, swelling rate, adhesion, rheological properties, antibacterial properties, in vitro biocompatibility, and in vivo animal experiments, the hydrogel has good injectability, biocompatibility, antibacterial (Staphylococcus aureus: 56.7 × 107 CFU/mL in the blank group and 2.5 × 107 CFU/mL in the 5/5 CPH group; Escherichia coli: 66.0 × 107 CFU/mL in the blank group and 8.5 × 107 CFU/mL in the 5/5 CPH group), and certain adhesion (0.71 kPa in the 5/5 CPH group) properties which can promote wound healing (wound healing reached 98.02% within 14 days in the 5/5 CPH group) and repair of cells with broad application prospects.

【 授权许可】

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Copyright © 2023 Fang, Lin, Fan, Qiu, Zhong, Yang, Yang, Zhang, Feng, Ai, Shi and Wan.