期刊论文详细信息
Frontiers in Nutrition
Deep eutectic solvent-ultrasound assisted extraction as a green approach for enhanced extraction of naringenin from Searsia tripartita and retained their bioactivities
Nutrition
Lamfeddal Kouisni1  Houda El Kahia1  Ezzouhra El Maaiden1  Abdelaziz Hirich1  Hassan Boukcim1  Youssef El Kharrassi1  Nagib Qarah2  Khadija Moustaid3  Boubker Nasser4 
[1] African Sustainable Agriculture Research Institute (ASARI), Mohammed VI Polytechnic University (UM6P), Laayoune, Morocco;Department of Chemistry, Faculty of Education-Zabid, Hodeidah University, Hodeidah, Yemen;Laboratory of Applied Chemistry and Environment, Hassan I University of Settat, Settat, Morocco;Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Hassan I University of Settat, Settat, Morocco;
关键词: anticholinesterase activity;    green extraction;    naringenin;    natural deep eutectic solvent;    response surface methodology;    Searsia tripartita;    skin aging;    ultrasonic-assisted extraction;   
DOI  :  10.3389/fnut.2023.1193509
 received in 2023-03-27, accepted in 2023-05-24,  发布年份 2023
来源: Frontiers
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【 摘 要 】

BackgroundNaringenin (NA) is a natural flavonoid used in the formulation of a wide range of pharmaceutical, fragrance, and cosmetic products. In this research, NA was extracted from Searsia tripartita using an environmentally friendly, high efficiency extraction method: an ultrasound-assisted extraction with deep eutectic solvents (UAE-DES).MethodsSix natural deep eutectic solvent systems were tested. Choline chloride was used as the hydrogen bond acceptor (HBA), and formic acid, ethylene glycol, lactic acid, urea, glycerol, and citric acid were used as hydrogen bond donors (HBD).ResultsBased on the results of single-factor experiments, response surface methodology using a Box-Behnken design was applied to determine the optimal conditions for UAE-DES. According to the results, the optimal NA extraction parameters were as follows: DES-1 consisted of choline chloride (HBA) and formic acid (HBD) in a mole ratio of 2:1, an extraction time of 10 min, an extraction temperature of 50°C, an ultrasonic amplitude of 75 W, and a solid-liquid ratio of 1/60 g/mL. Extracted NA was shown to inhibit the activity of different enzymes in vitro, including α-amylase, acetylcholinesterase, butyrylcholinesterase, tyrosinase, elastase, collagenase, and hyaluronidase.ConclusionThus, the UAE-DES technique produced high-efficiency NA extraction while retaining bioactivity, implying broad application potential, and making it worthy of consideration as a high-throughput green extraction method.

【 授权许可】

Unknown   
Copyright © 2023 El Maaiden, El Kahia, Nasser, Moustaid, Qarah, Boukcim, Hirich, Kouisni and El Kharrassi.

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