Anticholinesterase activity and chemical profile of an active chromatographic fraction of ethanolic extract from Bellis perennis L. (Asteraceae) flowers

Química Nova

Melo, Cassio Herbert Santos de¹  Universidade Federal da Bahia, Salvador, Brasil¹  Universidade Federal do Piauí, Teresina, Brasil¹  Lima, Luciano Silva¹  Carvalho, Rusbene Bruno Fonseca de¹  Marques, Thiago Henrique Costa¹  Santos, Pauline Sousa dos¹  David, Jorge Mauricio¹  Freitas, Rivelilson Mendes de¹  David, Juceni Pereira¹ 

关键词: anticholinesterase activity;    B. perennis;    isorhamnetin 3-O-β;    -D-(6''-acetyl)-galactopyranoside.;   

DOI  :  10.1590/S0100-40422013000400012

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work describes the isolation of an active flavonoid fraction and identification of isorhamnetin 3-O-β-D-(6''-acetyl)-galactopyranoside from flowers of B. perennis, and also the evaluation of anticholinesterase (AChE) activity of ethanolic extract from flowers (EEF) and the active fraction. The chemical structure of the flavonoid was defined on the basis of spectroscopic 1H NMR, IR and UV data. EEF or flavonoid reduces AChE activity in vivo, while flavonoid also reduces AChE activity in vitro, showing a value of 1.49 mM for 50% inhibitory concentration (IC50), suggesting potential use as an insecticide or in the treatment of neurodegenerative diseases such as Alzheimer's disease.

【 授权许可】

Unknown