期刊论文详细信息
Química Nova
Anticholinesterase activity and chemical profile of an active chromatographic fraction of ethanolic extract from Bellis perennis L. (Asteraceae) flowers
Melo, Cassio Herbert Santos de1  Universidade Federal da Bahia, Salvador, Brasil1  Universidade Federal do Piauí, Teresina, Brasil1  Lima, Luciano Silva1  Carvalho, Rusbene Bruno Fonseca de1  Marques, Thiago Henrique Costa1  Santos, Pauline Sousa dos1  David, Jorge Mauricio1  Freitas, Rivelilson Mendes de1  David, Juceni Pereira1 
关键词: anticholinesterase activity;    B. perennis;    isorhamnetin 3-O-β;    -D-(6''-acetyl)-galactopyranoside.;   
DOI  :  10.1590/S0100-40422013000400012
学科分类:化学(综合)
来源: Sociedade Brasileira de Quimica
PDF
【 摘 要 】

This work describes the isolation of an active flavonoid fraction and identification of isorhamnetin 3-O-β-D-(6''-acetyl)-galactopyranoside from flowers of B. perennis, and also the evaluation of anticholinesterase (AChE) activity of ethanolic extract from flowers (EEF) and the active fraction. The chemical structure of the flavonoid was defined on the basis of spectroscopic 1H NMR, IR and UV data. EEF or flavonoid reduces AChE activity in vivo, while flavonoid also reduces AChE activity in vitro, showing a value of 1.49 mM for 50% inhibitory concentration (IC50), suggesting potential use as an insecticide or in the treatment of neurodegenerative diseases such as Alzheimer's disease.

【 授权许可】

Unknown   

【 预 览 】
附件列表
Files Size Format View
RO201912050595993ZK.pdf 974KB PDF download
  文献评价指标  
  下载次数:1次 浏览次数:1次