Atividade anticolinesterásica e perfil químico de uma fração cromatográfica ativa do extrato etanólico das flores Bellis perennis L. (Asteraceae)

Química Nova

Thiago Henrique Costa Marques²  Pauline Sousa Dos Santos²  Rivelilson Mendes De Freitas²  Rusbene Bruno Fonseca De Carvalho¹  Cassio Herbert Santos De Melo¹  Juceni Pereira David¹  Jorge Mauricio David¹  Luciano Silva Lima¹ 

[1] ,Universidade Federal do Piauí Centro de Ciências da Saúde Departamento de Bioquímica e FarmacologiaTeresina PI ,Brasil

关键词: anticholinesterase activity;    B. perennis;    isorhamnetin 3-O-β-D-(6''-acetyl)-galactopyranoside;   

DOI  :  10.1590/S0100-40422013000400012

来源: SciELO

【 摘 要 】

This work describes the isolation of an active flavonoid fraction and identification of isorhamnetin 3-O-β-D-(6''-acetyl)-galactopyranoside from flowers of B. perennis, and also the evaluation of anticholinesterase (AChE) activity of ethanolic extract from flowers (EEF) and the active fraction. The chemical structure of the flavonoid was defined on the basis of spectroscopic ¹H NMR, IR and UV data. EEF or flavonoid reduces AChE activity in vivo, while flavonoid also reduces AChE activity in vitro, showing a value of 1.49 mM for 50% inhibitory concentration (IC50), suggesting potential use as an insecticide or in the treatment of neurodegenerative diseases such as Alzheimer's disease.

【 授权许可】

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