Anticholinesterase activity and chemical profile of an active chromatographic fraction of ethanolic extract from Bellis perennis L. (Asteraceae) flowers

Quimica nova

Lima, Luciano Silva¹  David, Jorge Mauricio¹  David, Juceni Pereira¹  Melo, Cassio Herbert Santos de²  Marques, Thiago Henrique Costa²  Carvalho, Rusbene Bruno Fonseca de²  Santos, Pauline Sousa dos²  Freitas, Rivelilson Mendes de² 

[1] Universidade Federal da Bahia, Salvador, Brasil;Universidade Federal do Piauí, Teresina, Brasil

关键词: anticholinesterase activity;    B. perennis;    isorhamnetin 3-O-β;    -D-(6''-acetyl)-galactopyranoside.;   

DOI  :  10.1590/S0100-40422013000400012

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work describes the isolation of an active flavonoidfraction and identification of isorhamnetin 3-O-β-D-(6''-acetyl)-galactopyranoside from flowers of B. perennis, and also the evaluation of anticholinesterase (AChE) activity of ethanolic extract from flowers (EEF) and the active fraction. The chemical structure of the flavonoid was defined on the basis of spectroscopic 1H NMR, IR and UV data. EEF or flavonoid reduces AChE activity in vivo, while flavonoid also reduces AChE activity in vitro, showing a value of 1.49 mM for 50% inhibitory concentration (IC50), suggesting potential use as an insecticide or in the treatment of neurodegenerative diseases such as Alzheimer's disease.

【 授权许可】

CC BY