Emergence of novel porcine circovirus 2d strains in Thailand, 2019–2020

Frontiers in Veterinary Science

Veterinary Science

Taveesak Janetanakit¹  Roongtham Kedkovid²  Chaitawat Sirisereewan³  Roongroje Thanawongnuwech⁴  Thanh Che Nguyen⁵ 

[1] Center of Excellence for Emerging and Re-emerging Infectious Diseases in Animals and One Health Research Cluster, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand;Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand;Center of Excellence in Swine Reproduction, Chulalongkorn University, Bangkok, Thailand;Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand;Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand;Center of Excellence for Emerging and Re-emerging Infectious Diseases in Animals and One Health Research Cluster, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand;The International Graduate Program of Veterinary Science and Technology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand;

关键词: porcine circovirus 2;    PCV2d;    mutation;    recombination;    pigs;    Thailand;   

DOI  :  10.3389/fvets.2023.1170499

 received in 2023-02-21, accepted in 2023-06-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Porcine circovirus 2 (PCV2) has been recognized as a causative agent of porcine circovirus diseases (PCVDs) affecting the global swine industry. In this study, the genetic diversity of PCV2 strains circulating in Thailand between 2019 and 2020 was investigated using 742 swine clinical samples from 145 farms. The results showed PCV2-positive rates of 54.2% (402/742) and 81.4% (118/145) at the sample and farm levels, respectively. Genetic analysis of 51 Thai PCV2 genomic sequences showed that 84.3% (43/51) was PCV2d, 13.7% (7/51) was PCV2b and 1.9% (1/51) was PCV2b/2d recombinant virus. Surprisingly, the majority of the Thai PCV2d sequences from this study (69.77%, 30/43) formed a novel cluster on a phylogenetic tree and contained a unique 133HDAM136 on the ORF2 deduced amino acid sequence, which is in one of the previously identified immunoreactive domains strongly involved in virus neutralization. The PCV2b/2d recombinant virus also carried 133HDAM136. The emergence of the novel PCV2d strains predominating in Thailand was discussed. This study highlights the need for further investigations on the spreading of these PCV2d strains in other regions and the efficacy of current commercial vaccines.

【 授权许可】

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Copyright © 2023 Sirisereewan, Nguyen, Janetanakit, Kedkovid and Thanawongnuwech.