Genotoxic effect of alkaloids

Memórias do Instituto Oswaldo Cruz

J. A. P. Henriques²  P. R. H. Moreno¹  G. L. Von Poser¹  C. C. Querol²  A. T. Henriques¹ 

[1] ,UFRGS Instituto de Biociências Departamento de Fisiologia, Farmacologia e BiofísicaPorto Alegre,Brasil

关键词: alkaloids;    SOS-Chromotest;    Saccharomyces cerevisiae;    mutation;    recombination;   

DOI  :  10.1590/S0074-02761991000600018

来源: SciELO

【 摘 要 】

Because of the increase use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryoticand eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotixicity in the presence of a metabolic activation mixture. Voacristine isolated fromthe leaves of Ervatamia coronaria shows in vivo cytostatic and mutagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.

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