Expression of nutrient transporters in placentas affected by gestational diabetes: role of leptin

Frontiers in Endocrinology

Endocrinology

Antonio Pérez-Pérez¹  Carmen Rodríguez-Chacón¹  Víctor Sánchez-Margalet¹  Carlos Jiménez-Cortegana¹  Flora Sánchez-Jiménez¹  Teresa Vilariño-García²  Isabel Corrales³  Pilar Guadix³  José L. Dueñas³ 

[1] Clinical Biochemistry Service, Virgen Macarena University Hospital and Department of Medical Biochemistry and Molecular Biology and Immunology, School of Medicine, University of Seville, Seville, Spain;Clinical Biochemistry Service, Virgen del Rocio University Hospital, School of Medicine, University of Seville, Seville, Spain;Obstetrics and Gynecology Service, Virgen Macarena University Hospital, School of Medicine, University of Seville, Seville, Spain;

关键词: gestational diabetes mellitus;    placental transport;    leptin;    glucose;    amino acids;    lipids;    fetal macrosomia;    nutrient transporters;   

DOI  :  10.3389/fendo.2023.1172831

 received in 2023-02-23, accepted in 2023-06-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Gestational diabetes mellitus (GDM) is the most frequent pathophysiological state of pregnancy, which in many cases produces fetuses with macrosomia, requiring increased nutrient transport in the placenta. Recent studies by our group have demonstrated that leptin is a key hormone in placental physiology, and its expression is increased in placentas affected by GDM. However, the effect of leptin on placental nutrient transport, such as transport of glucose, amino acids, and lipids, is not fully understood. Thus, we aimed to review literature on the leptin effect involved in placental nutrient transport as well as activated leptin signaling pathways involved in the expression of placental transporters, which may contribute to an increase in placental nutrient transport in human pregnancies complicated by GDM. Leptin appears to be a relevant key hormone that regulates placental transport, and this regulation is altered in pathophysiological conditions such as gestational diabetes. Adaptations in the placental capacity to transport glucose, amino acids, and lipids may underlie both under- or overgrowth of the fetus when maternal nutrient and hormone levels are altered due to changes in maternal nutrition or metabolic disease. Implementing new strategies to modulate placental transport may improve maternal health and prove effective in normalizing fetal growth in cases of intrauterine growth restriction and fetal overgrowth. However, further studies are needed to confirm this hypothesis.

【 授权许可】

Unknown   
Copyright © 2023 Guadix, Corrales, Vilariño-García, Rodríguez-Chacón, Sánchez-Jiménez, Jiménez-Cortegana, Dueñas, Sánchez-Margalet and Pérez-Pérez