Maternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta

International Journal of Molecular Sciences

Kendra Elizabeth Brett¹  Zachary Michael Ferraro³  Julien Yockell-Lelievre²  Andrພ Gruslin³ 

[1] Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario Research Institute, 401 Smyth Rd., Ottawa, ON K1H 8L1, Canada; E-Mail:;Ottawa Hospital Research Institute, Cancer Centre, 501 Smyth Rd., Ottawa, ON K1H 8L6, Canada; E-Mail:;Division of Maternal–Fetal Medicine, Obstetrics and Gynecology, the Ottawa Hospital, 501 Smyth Rd., Ottawa, ON K1H 8L6, Canada; E-Mail:

关键词: placental transport;    pregnancy;    maternal;    glucose;    amino acids;    fatty acids;    fetal growth;   

DOI  :  10.3390/ijms150916153

来源: mdpi

【 摘 要 】

Appropriate in utero growth is essential for offspring development and is a critical contributor to long-term health. Fetal growth is largely dictated by the availability of nutrients in maternal circulation and the ability of these nutrients to be transported into fetal circulation via the placenta. Substrate flux across placental gradients is dependent on the accessibility and activity of nutrient-specific transporters. Changes in the expression and activity of these transporters is implicated in cases of restricted and excessive fetal growth, and may represent a control mechanism by which fetal growth rate attempts to match availability of nutrients in maternal circulation. This review provides an overview of placenta nutrient transport with an emphasis on macro-nutrient transporters. It highlights the changes in expression and activity of these transporters associated with common pregnancy pathologies, including intrauterine growth restriction, macrosomia, diabetes and obesity, as well as the potential impact of maternal diet. Molecular signaling pathways linking maternal nutrient availability and placenta nutrient transport are discussed. How sexual dimorphism affects fetal growth strategies and the placenta’s response to an altered intrauterine environment is considered. Further knowledge in this area may be the first step in the development of targeted interventions to help optimize fetal growth.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.