High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19

Frontiers in Public Health

Public Health

Anders Magnuson¹  Ingela Marklund²  Emeli Månsson³  Mattias N. E. Forsell⁴  Christoffer Granvik⁴  Ida-Lisa Persson⁴  Clas Ahlm⁴  Johan Normark⁴  Anna Kauppi⁴  Sara Cajander⁵  Irma Ahmad⁵  Anna Lange⁵  Staffan Tevell⁶  Josefin Sundh⁷  Alicia Edin⁸  Lowa Kumm Persson⁸ 

[1] Center for Clinical Epidemiology and Biostatistics, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden;Centre for Clinical Research and Education, Region Värmland, Karlstad, Sweden;Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden;Centre for Clinical Research, Region Västmanland—Uppsala University, Västmanland Hospital Västerås, Västerås, Sweden;Department of Clinical Microbiology, Umeå University, Umeå, Sweden;Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden;Department of Infectious Diseases, Karlstad Hospital, Karlstad, Sweden;Centre for Clinical Research and Education, Region Värmland, Karlstad, Sweden;School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden;Department of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden;Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden;

关键词: COVID-19;    PACS;    long-COVID;    post-acute COVID syndrome (PACS);    EQ-5D;    SARS-CoV-2;    Post COVID-19 condition (PCC);   

DOI  :  10.3389/fpubh.2023.1104267

 received in 2022-11-21, accepted in 2023-01-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms and reduced health-related quality of life (HRQoL) in relation to functional exercise capacity, 6 months after infection, and explored risk factors for COVID-19 sequalae.MethodsThis was a prospective, multicenter, cohort study including 434 patients. At 6 months, physical exercise capacity was assessed by a 1-minute sit-to-stand test (1MSTST) and persistent symptoms were reported and HRQoL was evaluated through the EuroQol 5-level 5-dimension (EQ-5D-5L) questionnaire. Patients with both persistent symptoms and reduced HRQoL were classified into a new definition of post-acute COVID syndrome, PACS+. Risk factors for developing persistent symptoms, reduced HRQoL and PACS+ were identified by multivariable Poisson regression.ResultsPersistent symptoms were experienced by 79% of hospitalized, and 59% of non-hospitalized patients at 6 months. Hospitalized patients had a higher prevalence of self-assessed reduced overall health (28 vs. 12%) and PACS+ (31 vs. 11%). PACS+ was associated with reduced exercise capacity but not with abnormal pulse/desaturation during 1MSTST. Hospitalization was the most important independent risk factor for developing persistent symptoms, reduced overall health and PACS+.ConclusionPersistent symptoms and reduced HRQoL are common among COVID-19 survivors, but abnormal pulse and peripheral saturation during exercise could not distinguish patients with PACS+. Patients with severe infection requiring hospitalization were more likely to develop PACS+, hence these patients should be prioritized for clinical follow-up after COVID-19.

【 授权许可】

Unknown   
Copyright © 2023 Ahmad, Edin, Granvik, Kumm Persson, Tevell, Månsson, Magnuson, Marklund, Persson, Kauppi, Ahlm, Forsell, Sundh, Lange, Cajander and Normark.