期刊论文详细信息
Frontiers in Allergy
Sense of smell in chronic rhinosinusitis: A multicentric study on 811 patients
Allergy
Elena Cantone1  Stefania Gallo2  Alberto Macchi2  Claudia Staffieri3  Giancarlo Ottaviano4  Ignazio La Mantia5  Federica Cipolla5  Giulia Monti6  Veronica Seccia7  Angelo Ghidini8  Chiara Bianchini9  Umberto Barbone1,10  Marco Govoni1,11  Gabriele Orietti1,11  Alessandro Maselli Del Giudice1,12  Giacomo Sollini1,13  Ernesto Pasquini1,13  Alessia Giorli1,14  Giacomo Bertazzoni1,15  Enrico Heffler1,16  Luca Malvezzi1,16  Eugenio De Corso1,17  Andrea Ciofalo1,18  Carla De Vita1,19  Livio Presutti1,19  Cristina Di Lieto1,19  Federico Sireci2,20  Flavio Arnone2,21  Giorgia Carlotta Pipolo2,21  Alessio De Massimi2,22  Nicola Lombardo2,23  Giulia Gramellini2,24  Frank Rikki Canevari2,25 
[1] Department of Neuroscience, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat, Federico II University, Naples, Italy;ENT Clinic Asst Sette Laghi, University of Insubria, Varese, Italy;ENT Clinic Treviso, Treviso, Italy;ENT Clinic, Azienda Università Padova, Padova, Italy;ENT Clinic, University of Catania, Catania, Italy;ENT Clinic, University of Insubria, Varese, Italy;ENT Clinic, University of Pisa, Pisa, Italy;ENT Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy;ENT Department, Azienda Ospedaliera Universitaria S.Anna, Ferrara, Italy;ENT Department, Ospedale Provinciale Bolzano, Bolzano, Italy;ENT Department, University of Parma, Parma, Italy;ENT Unit Bari Adria Trani, Bari, Italy;ENT Unit Metropolitan Area, AUSL Bologna, Bologna, Italy;ENT Unit, University of Siena, Siena, Italy;Ent Clinic, Asst Cremona, Cremona, Italy;IRCCS Humanitas Research Hospital, Humanitas University Rozzano, Milano, Italy;Humanitas University, Pieve Emanuele (MI), Milano, Italy;Istituto di ORL, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy;Organ of Sense Department, Sapienza University of Rome, Roma, Italy;Otolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero Universitaria Policlinico di Sant-Orsola, Bologna, Italy;Otorhinolaryngology Section, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy;Otorhinolaryngology Unit ASST Santi Paolo e Carlo Hospital, Department of Health Sciences, University of Milan, Milan, Italy;SS ORL San Vito al Tagliamento - Azienda Sanitaria Friuli Occidentale, S. Vito al Tagliamento, Italy;UOC Azienda Ospedaliero Universitaria Mater Domini, Catanzaro, Italy;UOC Otorinolaringoiatria, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy;Unit of Otorhinolaryngology - IRCCS Ospedale Policlinico San Martino, Genova, Italy;
关键词: CRSwNP;    smell;    type 2;    QoL (quality of life);    olfactory dysfunction;   
DOI  :  10.3389/falgy.2023.1083964
 received in 2022-10-29, accepted in 2023-03-28,  发布年份 2023
来源: Frontiers
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【 摘 要 】

IntroductionThe impairment of the sense of smell is often related to chronic rhinosinusitis (CRS) with or without nasal polyps (CRSwNP, CRSsNP). CRSwNP is a frequent condition that drastically worsens the quality of life of those affected; it has a higher prevalence than CRSsNP. CRSwNP patients experience severe loss of smell with earlier presentation and are more likely to experience recurrence of their symptoms, often requiring revision surgery.MethodsThe present study performed a multicentric data collection, enrolling 811 patients with CRS divided according to the inflammatory endotype (Type 2 and non-Type 2). All patients were referred for nasal endoscopy for the assessment of nasal polyposis using nasal polyp score (NPS); Sniffin’ Sticks olfactory test were performed to measure olfactory function, and SNOT-22 (22-item sinonasal outcome test) questionnaire was used to assess patients’ quality of life; allergic status was evaluated with skin prick test and nasal cytology completed the evaluation when available.ResultsData showed that Type 2 inflammation is more common than non-type 2 (656 patients versus 155) and patients suffer from worse quality of life and nasal polyp score. Moreover, 86.1% of patients with Type 2 CRSwNP were affected by a dysfunction of the sense of smell while it involved a lesser percentage of non-Type 2 patients. Indeed, these data give us new information about type-2 inflammation patients’ characteristics.DiscussionThe present study confirms that olfactory function weights on patients’ QoL and it represents an important therapeutic goal that can also improve patients’ compliance when achieved. In a future – and present – perspective of rhinological precision medicine, an impairment of the sense of smell could help the clinician to characterize patients better and to choose the best treatment available.

【 授权许可】

Unknown   
© 2023 Macchi, Giorli, Cantone, Carlotta Pipolo, Arnone, Barbone, Bertazzoni, Bianchini, Ciofalo, Cipolla, De Massimi, De Vita, Di Lieto, Ghidini, Govoni, Gramellini, Maselli Del Giudice, Ottaviano, Seccia, Sireci, Sollini, Staffieri, Gallo, Heffler, Mantia, De Corso, Canevari, Lombardo, Malvezzi, Orietti, Pasquini, Presutti and Monti.

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