Orexin and MCH neurons: regulators of sleep and metabolism

Frontiers in Neuroscience

Neuroscience

Pawan Kumar Jha¹  Hanan Bouâouda² 

[1] Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany;

关键词: sleep;    metabolism;    orexin;    MCH;    feeding;    wake;    lateral hypothalamus;   

DOI  :  10.3389/fnins.2023.1230428

 received in 2023-05-28, accepted in 2023-08-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

Sleep-wake and fasting-feeding are tightly coupled behavioral states that require coordination between several brain regions. The mammalian lateral hypothalamus (LH) is a functionally and anatomically complex brain region harboring heterogeneous cell populations that regulate sleep, feeding, and energy metabolism. Significant attempts were made to understand the cellular and circuit bases of LH actions. Rapid advancements in genetic and electrophysiological manipulation help to understand the role of discrete LH cell populations. The opposing action of LH orexin/hypocretin and melanin-concentrating hormone (MCH) neurons on metabolic sensing and sleep-wake regulation make them the candidate to explore in detail. This review surveys the molecular, genetic, and neuronal components of orexin and MCH signaling in the regulation of sleep and metabolism.

【 授权许可】

Unknown   
Copyright © 2023 Bouâouda and Jha.