Functional diversity of staphylococcal surface proteins at the host-microbe interface

Frontiers in Microbiology

Microbiology

Nicoletta Schwermann¹  Volker Winstel¹ 

[1] Research Group Pathogenesis of Bacterial Infections, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture Between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany;Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany;

关键词: Staphylococcus aureus;    surface proteins;    sortase A;    abscess;    vaccine;   

DOI  :  10.3389/fmicb.2023.1196957

 received in 2023-03-30, accepted in 2023-04-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Surface proteins of Gram-positive pathogens are key determinants of virulence that substantially shape host-microbe interactions. Specifically, these proteins mediate host invasion and pathogen transmission, drive the acquisition of heme-iron from hemoproteins, and subvert innate and adaptive immune cell responses to push bacterial survival and pathogenesis in a hostile environment. Herein, we briefly review and highlight the multi-facetted roles of cell wall-anchored proteins of multidrug-resistant Staphylococcus aureus, a common etiological agent of purulent skin and soft tissue infections as well as severe systemic diseases in humans. In particular, we focus on the functional diversity of staphylococcal surface proteins and discuss their impact on the variety of clinical manifestations of S. aureus infections. We also describe mechanistic and underlying principles of staphylococcal surface protein-mediated immune evasion and coupled strategies S. aureus utilizes to paralyze patrolling neutrophils, macrophages, and other immune cells. Ultimately, we provide a systematic overview of novel therapeutic concepts and anti-infective strategies that aim at neutralizing S. aureus surface proteins or sortases, the molecular catalysts of protein anchoring in Gram-positive bacteria.

【 授权许可】

Unknown   
Copyright © 2023 Schwermann and Winstel.