Chlorin e6-modified iron oxide nanoparticles for photothermal-photodynamic ablation of glioblastoma cells

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Hongqing Yao¹  Jian-Ying Zhou² 

[1] Department of Nursing Care, Shanghai Songjiang District Central Hospital, Shanghai, China;null;

关键词: glioblastoma;    iron oxide nanoparticles;    photothermal therapy;    photodynamic therapy;    cancer therapy;   

DOI  :  10.3389/fbioe.2023.1248283

 received in 2023-06-27, accepted in 2023-07-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: The effective treatment of glioblastoma still remains a great challenge. We herein report the development of chlorin e6 (Ce6)-conjugated iron oxide (Fe3O4-Ce6) nanoparticles for ablation of glioblastoma cells via combining photothermal therapy (PTT) with photodynamic therapy (PDT).Methods: Ce6 was conjugated to the synthesized Fe3O4 nanoparticles to form Fe3O4-Ce6 nanoparticles displaying the optical property of Ce6.Results and discussion: Under 808 nm laser irradiation, Fe3O4-Ce6 nanoparticles generated heat and the temperature increase did not have obvious changes after five cycles of laser irradiation, suggesting their good photothermal effect and photothermal stability. In addition, 660 nm laser irradiation of Fe3O4-Ce6 nanoparticles produced singlet oxygen (1O2) to mediate PDT. The Fe3O4-Ce6 nanoparticles without laser irradiation showed a low cytotoxicity, but they would obviously kill C6 cancer cells after laser irradiation via the combinational effect of PTT and PDT. Fe3O4-Ce6 nanoparticles thus could be used as a nanotherapeutic agent for combinational ablation of glioblastoma cells.

【 授权许可】

Unknown   
Copyright © 2023 Yao and Zhou.