Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies

Nanomaterials

卷:11

Ulf P. Neumann¹  Lea Eckstein¹  Julian Palzer¹  Anjali A. Roeth¹  Ioana Slabu²  Oliver Reisen² 

[1] Department of General, Visceral and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany;

[2] Institute of Applied Medical Engineering, Helmholtz Institute Aachen, RWTH Aachen University Hospital, 52074 Aachen, Germany;

关键词: iron oxide nanoparticles;    magnetic fluid hyperthermia;    photothermal therapy;    cancer;   

DOI  :  10.3390/nano11113013

来源: DOAJ

【 摘 要 】

Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Néel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.

【 授权许可】

Unknown