Indocyanine green-loaded perfluorocarbon nanoemulsions for bimodal19 F-magnetic resonance/nearinfrared fluorescence imaging and subsequent phototherapy

Quantitative Imaging in Medicine and Surgery

Saehun Mun¹  Yongdoo Choi²  Daehong Kim²  Yuan-Guo Wang²  Hyunjin Kim² 

[1] Center for Food and Bioconvergence, Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-742, Republic of KoreaMolecular Imaging and Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea;

关键词: Indocyanine green;    perfluorocarbon;    19F-magnetic resonance imaging;    near-infrared fluorescence imaging;    photodynamic therapy;    photothermal therapy;   

DOI  :  10.3978/j.issn.2223-4292.2013.06.03

学科分类：外科医学

来源: AME Publications

【 摘 要 】

We have developed an indocyanine green-loaded perfluorocarbon (ICG/PFCE) nanoemulsion as a multifunctional theranostic nanomedicine which enables not only ¹⁹F magnetic resonance (MR)/near-infrared fluorescence (NIRF) bimodal imaging but also subsequent photodynamic/photothermal dual therapy of cancer. The hydrodynamic size of ICG/PFCE nanoemulsions was 164.2 nm. The stability of indocyanine green (ICG) in aqueous solution was significantly improved when loaded on perfluorocarbon nanoemulsions. In addition, ICG/PFCE nanoemulsions showed good dispersion stability in aqueous media containing 10% fetal bovine serum, for at least 14 days.

【 授权许可】

Unknown