Quantitative Imaging in Medicine and Surgery | |
Indocyanine green-loaded perfluorocarbon nanoemulsions for bimodal19 F-magnetic resonance/nearinfrared fluorescence imaging and subsequent phototherapy | |
Saehun Mun1  Yongdoo Choi2  Daehong Kim2  Yuan-Guo Wang2  Hyunjin Kim2  | |
[1] Center for Food and Bioconvergence, Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-742, Republic of KoreaMolecular Imaging and Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea; | |
关键词: Indocyanine green; perfluorocarbon; 19F-magnetic resonance imaging; near-infrared fluorescence imaging; photodynamic therapy; photothermal therapy; | |
DOI : 10.3978/j.issn.2223-4292.2013.06.03 | |
学科分类:外科医学 | |
来源: AME Publications | |
【 摘 要 】
We have developed an indocyanine green-loaded perfluorocarbon (ICG/PFCE) nanoemulsion as a multifunctional theranostic nanomedicine which enables not only 19F magnetic resonance (MR)/near-infrared fluorescence (NIRF) bimodal imaging but also subsequent photodynamic/photothermal dual therapy of cancer. The hydrodynamic size of ICG/PFCE nanoemulsions was 164.2 nm. The stability of indocyanine green (ICG) in aqueous solution was significantly improved when loaded on perfluorocarbon nanoemulsions. In addition, ICG/PFCE nanoemulsions showed good dispersion stability in aqueous media containing 10% fetal bovine serum, for at least 14 days.
【 授权许可】
Unknown
【 预 览 】
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