Identity crisis of nanostructures inside the human body: a perspective on inflammation

Frontiers in Nanotechnology

Nanotechnology

Sarmistha Saha¹  Luciano Saso² 

[1] Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura, Uttar Pradesh, India;Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, Rome, Italy;

关键词: nanotechnology;    protein corona;    inflammation;    sustainability;    cellular uptake;   

DOI  :  10.3389/fnano.2023.1256952

 received in 2023-07-11, accepted in 2023-08-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Advances in nanotechnology have attracted a lot of potential medical applications, such as therapeutic agents, diagnostics, and theranostics for complex diseases. The intersection of nanotechnologies, molecular and cell biology, and medicine can function to improve human health and quality of life, making healthcare a primary target of nanotechnology research. However, this seems like a promising future, ethical, health, and safety concerns must be considered before a reasoned evaluation of the situation can be made. Most nanostructures, however, typically fail to reach their intended targets because they get trapped inside innate immune cells. Since little is known about how nanomaterials and nanotechnologies change their identity inside the biological system, there is a wide-ranging discussion on possible concerns. In this regard, we present a perspective on how biological systems may interact with nanoscale materials and how that interaction might affect cellular recognition of nanostructures. We will also discuss dynamic modifications of the nanomaterials inside biological systems and, in particular, inflammation responses.

【 授权许可】

Unknown   
Copyright © 2023 Saha and Saso.