Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Ling He¹  Qiang Zhang¹  Jiantong Sun²  Jixuan Zheng²  Jinting Jiang²  Tingrui Xu²  Xiao Liang²  Yicheng Pu² 

[1] Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, West China School of Medicine, West China School of Pharmacy, Sichuan University, Chengdu, China;

关键词: tumor-associated macrophage;    nanoparticle;    tumor micorenvironment targeting;    nanoparticle delivery;    antitumor therapy;   

DOI  :  10.3389/fbioe.2023.1248421

 received in 2023-06-27, accepted in 2023-08-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Targeting tumor-associated macrophages (TAMs) has emerged as a promising approach in cancer therapy. This article provides a comprehensive review of recent advancements in the field of nanomedicines targeting TAMs. According to the crucial role of TAMs in tumor progression, strategies to inhibit macrophage recruitment, suppress TAM survival, and transform TAM phenotypes are discussed as potential therapeutic avenues. To enhance the targeting capacity of nanomedicines, various approaches such as the use of ligands, immunoglobulins, and short peptides are explored. The utilization of live programmed macrophages, macrophage cell membrane-coated nanoparticles and macrophage-derived extracellular vesicles as drug delivery platforms is also highlighted, offering improved biocompatibility and prolonged circulation time. However, challenges remain in achieving precise targeting and controlled drug release. The heterogeneity of TAMs and the variability of surface markers pose hurdles in achieving specific recognition. Furthermore, the safety and clinical applicability of these nanomedicines requires further investigation. In conclusion, nanomedicines targeting TAMs hold great promise in cancer therapy, offering enhanced specificity and reduced side effects. Addressing the existing limitations and expanding our understanding of TAM biology will pave the way for the successful translation of these nano-therapies into clinical practice.

【 授权许可】

Unknown   
Copyright © 2023 Zheng, Jiang, Pu, Xu, Sun, Zhang, He and Liang.