Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy

Cells

ClodaghP. O’Neill¹  RóisínM. Dwyer¹ 

[1] Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, H91 YR71 Galway, Ireland;

关键词: tumor suppressor mirna;    cancer therapy;    nanoparticle delivery;   

DOI  :  10.3390/cells9020521

来源: DOAJ

【 摘 要 】

Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo.

【 授权许可】

Unknown