Pentacyclic triterpenoids saponins pannosides A-E from Tripolium pannonicum

Frontiers in Marine Science

Marine Science

Seung Hyun Kim¹  Yechan Lee¹  Wan Namkung¹  Soohyun Um¹  Jaeyoun Lee¹ 

[1] College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea;

关键词: Tripolium pannonicum;    halophyte;    pentacyclic triterpenoids;    saponins;    cytotoxicity;   

DOI  :  10.3389/fmars.2023.1117407

 received in 2022-12-06, accepted in 2023-02-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

Five previously undescribed pentacyclic triterpenoid saponins, pannoside A–E (1–5), were discovered from the whole plant of seashore aster, Tripolium pannonicum, collected from the Songdo tidal flat, Incheon, Korea. The planar structures of pannosides were elucidated as pentacyclic triterpenoids bearing sugar moieties and 3-hydroxybutyrate (3-HB) based on the interpretation of the NMR, IR spectroscopic and MS data. The relative configurations of the aglycone and sugar moieties of 1–5 were determined based on careful analysis of ROESY correlations. To determine the absolute configuration of 3-hydroxybutyrate, we utilized the phenylglycine methyl ester (PGME) derivatization with LC-MS chromatographic analysis. Pannoside E (5) exhibited inhibitory activities against diverse cancer cell lines including prostate carcinoma and non-small cell lung carcinoma, with IC50 values of 0.34 and 0.89 μM, respectively. Pannosides are the first triterpenoid saponin isolated from T. pannonicum, implying that undiscovered secondary metabolites from a halophyte could be a good source of bioactive compounds.

【 授权许可】

Unknown   
Copyright © 2023 Um, Lee, Lee, Namkung and Kim