Microbial-Catalyzed Biotransformation of Multifunctional Triterpenoids Derived from Phytonutrients

International Journal of Molecular Sciences

Munawar Hussain¹  Huey Ling Tan²  Muhammad Afifi Bin Mohd Faridz³  Sadia Sultan³  Syed Adnan Ali Shah³  Sharifah Nurfazilah³  Mohamad Azlan Bin Mohd Shah³ 

[1] Department of Basic Sciences, DHA Suffa University, Off, Khayaban-e-Tufail, Phase VII (Extension), DHA, Karachi 75500, Pakistan;Faculty of Chemical Engineering, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia;Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus,42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia;

关键词: microbial transformation;    tetranortriterpenoids;    tetracyclic triterpenoids;    pentacyclic triterpenoids;    biocatalysis;   

DOI  :  10.3390/ijms150712027

来源: DOAJ

【 摘 要 】

Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids.

【 授权许可】

Unknown