期刊论文详细信息
International Journal of Molecular Sciences
Microbial-Catalyzed Biotransformation of Multifunctional Triterpenoids Derived from Phytonutrients
Syed Adnan Ali Shah1  Huey Ling Tan2  Sadia Sultan1  Muhammad Afifi Bin Mohd Faridz1  Mohamad Azlan Bin Mohd Shah1  Sharifah Nurfazilah1 
[1] Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; E-Mails:;Faculty of Chemical Engineering, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia
关键词: microbial transformation;    tetranortriterpenoids;    tetracyclic triterpenoids;    pentacyclic triterpenoids;    biocatalysis;   
DOI  :  10.3390/ijms150712027
来源: mdpi
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【 摘 要 】

Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

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