Pentacyclic Triterpenoids from Sabia discolor Dunn and Their α-Glycosidase Inhibitory Activities

Molecules

Lu-Lu Deng¹  Shu-Zhen Mu¹  Dan Hu¹  Jiang Li¹  Jin-Hong Ma¹  Xiao-Jiang Hao¹ 

[1] State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China;

关键词: Sabia discolor Dunn;    pentacyclic triterpenoids;    isolation and purification;    α-glycosidase inhibitory activities;   

DOI  :  10.3390/molecules27072161

来源: DOAJ

【 摘 要 】

Four new pentacyclic triterpenoids named Sabiadiscolor A–D (1 and 7–9) together with eleven known ones were isolated by repeated column chromatography. Their structures were identified and characterized by NMR and MS spectral data as 6 oleanane-type pentacyclic triterpenoids (1–6), 7 ursane-type ones (7–13), and 2 lupanane-type ones (14–15). Except for compound 15, all other compounds were isolated from Sabia discolor Dunn for the first time. Their α-glycosidase inhibitory activities were evaluated, which showed that compounds 1, 3, 8, 9, 13, and 15 implied remarkable activities with IC₅₀ values ranging from 0.09 to 0.27 μM, and the preliminary structure–activity relationship was discussed.

【 授权许可】

Unknown