Coating of manganese functional polyetheretherketone implants for osseous interface integration

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Yinchang Zhang¹  Lei Wang¹  Huazheng He¹  Xin Yang¹  Pingbo Chen¹  Shouliang Xiong¹  Congming Li¹  Qiang Wang¹  Zhiqiang Shao²  Jing Zhou² 

[1] Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China;Orthopedics and Sports Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China;

关键词: PEEK;    manganese;    polydopamine;    biocompatibility;    osseointegration;   

DOI  :  10.3389/fbioe.2023.1182187

 received in 2023-03-08, accepted in 2023-04-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

Polyetheretherketone (PEEK) has been used extensively in biomedical engineering and it is highly desirable for PEEK implant to possess the ability to promote cell growth and significant osteogenic properties and consequently stimulate bone regeneration. In this study, a manganese modified PEEK implant (PEEK-PDA-Mn) was fabricated via polydopamine chemical treatment. The results showed that manganese was successfully immobilized on PEEK surface, and the surface roughness and hydrophilicity significantly improved after surface modification. Cell experiments in vitro demonstrated that the PEEK-PDA-Mn possesses superior cytocompatibility in cell adhesion and spread. Moreover, the osteogenic properties of PEEK-PDA-Mn were proved by the increased expression of osteogenic genes, alkaline phosphatase (ALP), and mineralization in vitro. Further rat femoral condyle defect model was utilized to assess bone formation ability of different PEEK implants in vivo. The results revealed that the PEEK-PDA-Mn group promoted bone tissue regeneration in defect area. Taken together, the simple immersing method can modify the surface of PEEK, giving outstanding biocompatibility and enhanced bone tissue regeneration ability to the modified PEEK, which could be applied as an orthopedic implant in clinical.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Xiong, Zhou, Zhang, He, Chen, Li, Wang, Shao and Wang.