Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes

International Journal of Molecular Sciences

Khachatur Julfakyan²  Yevhen Fatieiev²  Shahad Alsaiari²  Lin Deng²  Alaa Ezzeddine²  Dingyuan Zhang²  Vincent M. Rotello¹  Niveen M. Khashab² 

[1] Department of Chemistry, University of Massachusetts Amherst, Amherst, MA 01003, USA; E-Mail:;Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia; E-Mails:

关键词: FeCo nanocubes;    polydopamine;    microwave radiation;    nanomedicine;   

DOI  :  10.3390/ijms160818283

来源: mdpi

【 摘 要 】

Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm² power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.