Effects of surface chemistry and surface topography on polyether-ether-ketone osseointegration

PEEK;Osseointegration;Porous;Orthopaedics;Spinal fusion

Torstrick, Frederick Brennan ; Guldberg, Robert E. Gall, Ken Mechanical Engineering Boden, Scott Garcia, Andres Murphy, William ; Guldberg, Robert E.

University:Georgia Institute of Technology

Department:Mechanical Engineering

关键词: PEEK;    Osseointegration;    Porous;    Orthopaedics;    Spinal fusion;   

Others  :  https://smartech.gatech.edu/bitstream/1853/60711/1/TORSTRICK-DISSERTATION-2017.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

Osseointegration of a novel porous polymer material made from polyether-ether-ketone (PEEK) was investigated using in vitro cell models and in vivo small animal models. Porous PEEK was compared to conventional smooth PEEK surfaces and plasma-sprayed titanium coated PEEK surfaces. The relative effects of surface material and surface topography were also investigated utilizing nano-scale atomic layer deposition (ALD) coatings. Histological, micro-computed tomography and biomechanical outcomes support that the porous PEEK material facilitated bone ingrowth and implant fixation compared to other surfaces. These results could provide valuable insight for the development of more effective devices for spinal fusions and other orthopaedic applications.