Polyetheretherketone implants with hierarchical porous structure for boosted osseointegration

Biomaterials Research

Research Article

JiaJia Deng¹  Yuehua Liu¹  Qingqing Wang²  Lin Yu³  Jiandong Ding³  Zhiyong Chen³  Yu Chen³  Xin Wang³  Yang Wang³ 

[1] Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, 200001, Shanghai, China;Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, 310016, Hangzhou, Zhejiang, China;State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, 200438, Shanghai, China;

关键词: PEEK;    Surface modification;    Biomaterials;    Cold pressing;    Hierarchical porous structure;    Osseointegration;   

DOI  :  10.1186/s40824-023-00407-5

 received in 2023-04-03, accepted in 2023-06-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundGood osseointegration is the key to the long-term stability of bone implants. Thermoplastic polyetheretherketone (PEEK) has been widely used in orthopedics; however, its inherent biological inertia causes fibrous tissue to wrap its surface, which leads to poor osseointegration and thus greatly limits its clinical applications.MethodsHerein, we developed a facile yet effective surface modification strategy. A commonly used sulfonation coupled with “cold pressing” treatment in the presence of porogenic agent formed a three-dimensional hierarchical porous structure on PEEK surface. Subsequently, the effects of porous surface on the in vitro adhesion, proliferation and differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs) were evaluated. Finally, the osteoinduction and osseointegration of surface-porous PEEK implant were examined in the rat distal femoral defect model.ResultsIn vitro results showed that the surface modification did not significantly affect the mechanical performance and cytocompatibility of PEEK substance, and the porous structure on the modified PEEK substrate provided space for cellular ingrowth and enhanced osteogenic differentiation and mineralization of BMSCs. In vivo tests demonstrated that the surface-porous PEEK implant could effectively promote new bone formation and had higher bone-implant contact rate, thereby achieving good bone integration with the surrounding host bone. In addition, this modification technique was also successfully demonstrated on a medical PEEK interbody fusion cage.ConclusionThe present study indicates that topological morphology plays a pivotal role in determining implant osseointegration and this facile and effective modification strategy developed by us is expected to achieve practical applications quickly.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

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