Tubeimuside I improves the efficacy of a therapeutic Fusobacterium nucleatum dendritic cell-based vaccine against colorectal cancer

Frontiers in Immunology

Immunology

Hongwu Sun¹  Shanhu Hao²  Yanan Tong²  Guoxu Zhang²  Zhiguo Wang²  Guoxiu Lu³ 

[1] Department of Microbiology and Biochemical Pharmacy, National Engineering Research Center of Immunological Products, College of Pharmacy, Third Military Medical University, Chongqing, China;Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang, China;Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang, China;College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning, China;

关键词: colorectal cancer;    F. nucleatum;    tubeimuside I;    dendritic cells;    vaccine;   

DOI  :  10.3389/fimmu.2023.1154818

 received in 2023-01-31, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionFusobacterium nucleatum (F. nucleatum) infection has been confirmed to be associated with the development, chemoresistance, and immune evasion of colorectal cancer (CRC). The complex relationship between the microorganism, host cells, and the immune system throughout all stages of CRC progression, which makes the development of new therapeutic methods difficult.MethodsWe developed a new dendritic cell (DC) vaccine to investigate the antitumor efficacy of CRC immunotherapy strategies. By mediating a specific mode of interaction between the bacteria, tumor, and host, we found a new plant-derived adjuvant, tubeimuside I (TBI), which simultaneously improved the DC vaccine efficacy and inhibited the F. nucleatum infection. Encapsulating TBI in a nanoemulsion greatly improved the drug efficacy and reduced the drug dosage and administration times.ResultsThe nanoemulsion encapsulated TBI DC vaccine exhibited an excellent antibacterial and antitumor effect and improved the survival rate of CRC mice by inhibiting tumor development and progression.DiscussionIn this study, we provide a effective strategy for developing a DC-based vaccine against CRC and underlies the importance of further understanding the mechanism of CRC processes caused by F. nucleatum.

【 授权许可】

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Copyright © 2023 Tong, Lu, Wang, Hao, Zhang and Sun