Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer

Frontiers in Oncology

Cheok S. Lee¹  Stephen M. Riordan⁵  Seul A. Lee⁶  Fang Liu⁶  Li Zhang⁶ 

[1] Department of Anatomical Pathology, Liverpool Hospital, Sydney, NSW, Australia;Discipline of Pathology, School of Medicine, Western Sydney University, Sydney, NSW, Australia;Faculty of Medicine and Health, Central Clinical School, University of Sydney, Sydney, NSW, Australia;Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia;Gastrointestinal and Liver Unit, Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia;School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia;

关键词: colorectal cancer;    CRC;    Fusobacterium nucleatum;    F. nucleatum;    tumorigenic mechanisms;   

DOI  :  10.3389/fonc.2019.00566

来源: DOAJ

【 摘 要 】

Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the association between F. nucleatum and CRC, the detection methods and the tumorigenic mechanisms. Furthermore, we discuss the potential clinical impact of F. nucleatum in CRC and suggest future study directions.

【 授权许可】

Unknown