Fusobacterium nucleatum and oral cancer: a critical review

BMC Cancer

Gerard J. Linden¹  Emily McIlvanna²  Stephanie G. Craig³  Jacqueline A. James⁴  Fionnuala T. Lundy⁵ 

[1] Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, Northern Ireland, UK;Patrick G Johnson Centre for Cancer Research, Queen’s University Belfast, Belfast, Northern Ireland, UK;Patrick G Johnson Centre for Cancer Research, Queen’s University Belfast, Belfast, Northern Ireland, UK;Precision Medicine Centre of Excellence, Health Sciences Building, Queen’s University Belfast, Belfast, Northern Ireland, UK;Patrick G Johnson Centre for Cancer Research, Queen’s University Belfast, Belfast, Northern Ireland, UK;Precision Medicine Centre of Excellence, Health Sciences Building, Queen’s University Belfast, Belfast, Northern Ireland, UK;Northern Ireland Biobank, Health Sciences Building, Queen’s University Belfast, Belfast, Northern Ireland, UK;Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, Northern Ireland, UK;

关键词: Fusobacteria;    F. nucleatum;    Carcinogenesis;    Oral cancer;    OSCC;   

DOI  :  10.1186/s12885-021-08903-4

来源: Springer

【 摘 要 】

There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include Helicobacter pylori-mediated inflammation in gastric cancer and more recently Fusobacterium nucleatum-mediated inflammation in colorectal cancer. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F. nucleatum, which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that F. nucleatum can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between F. nucleatum and oral carcinogenesis, and provides insights into the possible mechanisms underlying it.

【 授权许可】

CC BY