Exosomal miRNAs as novel avenues for breast cancer treatment

Frontiers in Genetics

Genetics

Hardeep Singh Tuli¹  Vijay Singh²  Mahesh Kaushik³  Lokesh Chandra Mishra⁴  Tejveer Singh⁴  Chesta Behl⁴ 

[1] Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Ambala, India;Immunology and Infectious Disease Biology Lab, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India;Radiation and Cancer Therapeutics Lab, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India;Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi, India;

关键词: breast cancer;    exosome;    miRNA;    diagnosis;    metastasis;   

DOI  :  10.3389/fgene.2023.1134779

 received in 2022-12-30, accepted in 2023-02-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Breast cancer is the most commonly diagnosed cancer and a leading cause of death in women worldwide. It is a heterogeneous disease, as shown by the gene expression profiles of breast cancer samples. It begins in milk-producing ducts, with a high degree of diversity between and within tumors, as well as among cancer-bearing individuals. The enhanced prevalence of breast cancer is influenced by various hormonal, lifestyle, and environmental factors, and very early onset of the disease correlates strongly with the risk of local and distant recurrence. Many subtypes are difficult to treat with conventional therapeutic modalities, and therefore, optimal management and early diagnosis are the first steps to minimizing the mortality linked with breast cancer. The use of newer methods of nanotechnology extends beyond the concept of synthesizing drug delivery mechanisms into the creation of new therapeutics, such as delivering chemotherapeutics with nanomaterial properties. Exosomes, a class of nanovesicles, are emerging as novel tools for deciphering the patient-specific proteins and biomarkers across different disease models, including breast cancer. In this review, we address the role of exosomal miRNA in breast cancer diagnosis and treatment.

【 授权许可】

Unknown   
Copyright © 2023 Singh, Kaushik, Mishra, Behl, Singh and Tuli.