Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment

Frontiers in Oncology

Oncology

Ketao Jin¹  Jun Qian²  Xingliang Fang³  Huanrong Lan⁴ 

[1] Department of Colorectal Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China;Department of Colorectal Surgery, Xinchang People’s Hospital, Affiliated Xinchang Hospital, Wenzhou Medical University, Xinchang, Zhejiang, China;Department of Hepatobiliary Surgery, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China;Department of Surgical Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, China;

关键词: pancreatic cancer;    exosome;    diagnosis;    prognosis;    tumor;    treatment;    miRNA;   

DOI  :  10.3389/fonc.2023.1149551

 received in 2023-01-22, accepted in 2023-05-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Pancreatic cancer (PC) is one of the most dangerous diseases that threaten human life, and investigating the details affecting its progression or regression is particularly important. Exosomes are one of the derivatives produced from different cells, including tumor cells and other cells such as Tregs, M2 macrophages, and MDSCs, and can help tumor growth. These exosomes perform their actions by affecting the cells in the tumor microenvironment, such as pancreatic stellate cells (PSCs) that produce extracellular matrix (ECM) components and immune cells that are responsible for killing tumor cells. It has also been shown that pancreatic cancer cell (PCC)-derived exosomes at different stages carry molecules. Checking the presence of these molecules in the blood and other body fluids can help us in the early stage diagnosis and monitoring of PC. However, immune system cell-derived exosomes (IEXs) and mesenchymal stem cell (MSC)-derived exosomes can contribute to PC treatment. Immune cells produce exosomes as part of the mechanisms involved in the immune surveillance and tumor cell-killing phenomenon. Exosomes can be modified in such a way that their antitumor properties are enhanced. One of these methods is drug loading in exosomes, which can significantly increase the effectiveness of chemotherapy drugs. In general, exosomes form a complex intercellular communication network that plays a role in developing, progressing, diagnosing, monitoring, and treating pancreatic cancer.

【 授权许可】

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Copyright © 2023 Fang, Lan, Jin and Qian