Is there an association between a plant-based eating pattern and clinical findings of a migraine headache?

Frontiers in Nutrition

Nutrition

Elham Karimi¹  Shahnaz Amani Tirani²  Arman Arab²  Gholamreza Askari²  Atefeh As’habi³  Elham Sadat Azimi⁴ 

[1] Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran;Research Development Center, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran;Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran;Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran;Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran;

关键词: plant-based diet index;    migraine;    headache;    diet;    integrative medicine;    Iran;   

DOI  :  10.3389/fnut.2023.1117740

 received in 2022-12-06, accepted in 2023-06-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

AimsThe present study was conducted among Iranian individuals diagnosed with migraine headaches to investigate the association between plant-based eating patterns and the clinical features of a migraine headache.MethodsIn total, 262 patients aged 20–50 years who were diagnosed with migraine headaches were included in the current cross-sectional study. Participants’ dietary intake was assessed using a validated 168-item, semi-quantitative food frequency questionnaire (FFQ). Three versions of the plant-based diet index (PDI) comprising overall PDI, healthy PDI (hPDI), and unhealthy PDI (uPDI) were generated. Headache frequency, duration, and severity were assessed via a 30-day headache diary. Migraine-related disability was assessed with a validated version of the headache impact test (HIT-6) questionnaire. Serum nitric oxide (NO) was measured using the Griess method utilizing serum samples.ResultsAfter controlling for potential confounders, an increase in mean PDI score from 48.22 to 61.67 decreased the frequency of headaches by −2.95 (95% CI: 0.06, 0.53; ptrend = 0.005). PDI was inversely associated with serum levels of NO in those with the highest scores of PDI compared to those with the lowest scores after adjustment for confounders (β = −7.69; 95% CI: −14.68, −0.69; ptrend = 0.028). After adjustment for potential confounders, an increase in the mean hPDI score from 47.96 to 65.25 decreased serum levels of NO by −11.92 (95% CI: −19.74, −4.10; ptrend = 0.003).ConclusionOur findings suggest that higher adherence to a plant-based eating style, as evidenced by higher PDI and hPDI values, was significantly associated with lower headache frequency and serum levels of NO.

【 授权许可】

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Copyright © 2023 Karimi, Tirani, Azimi, Askari, As’habi and Arab.