Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins

Toxins

Sara M. Schaefer¹  Christopher H. Gottschalk²  Bahman Jabbari² 

[1] Department of Neurology, Yale University, 20 York St., New Haven, CT 06510, USA;

关键词: botulinum toxin;    migraine;    headache;    chronic migraine;    chronic daily headache;    neurotoxins;    medication overuse headache;   

DOI  :  10.3390/toxins7072615

来源: mdpi

【 摘 要 】

Migraine is the most common neurological disorder, and contributes to disability and large healthcare costs in the United States and the world. The treatment of migraine until recently has focused on medications, both abortive and prophylactic, but treatment of chronic migraine has been revolutionized with the introduction of botulinum toxin injection therapy. In this review, we explore the current understanding of migraine pathophysiology, and the evolution of the use of botulinum toxin therapy including proposed pathophysiological mechanisms through animal data. We also discuss the similarities and differences between three injection techniques.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.