Abnormal left atrial compliance is associated with a history of life-threatening arrhythmia in corrected Tetralogy of Fallot

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Pierre Ollitrault¹  Pascale Maragnes¹  Clémence Macquaire¹  Cynthia Cousergue¹  Mathilde Vautier¹  Fabien Labombarda²  Benoit Mulet³  Camille-Océane André³ 

[1] Department of Cardiology, CHU de Caen-Normandie, Caen, France;Department of Cardiology, Normandie Univ, UNICAEN, CHU Caen-Normandie, UR PSIR 4650, Unicaen, Caen, France;Department of Pediatrics, CHU de Caen-Normandie, Caen, France;

关键词: strain;    congenital heart disease;    sudden cardiac death;    ventricular arrhythmia;    compliance;   

DOI  :  10.3389/fcvm.2023.1161017

 received in 2023-02-07, accepted in 2023-04-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesThe objectives of this study were to examine left atrial (LA) function and compliance using two-dimensional (2D) strain analysis in adult patients with corrected Tetralogy of Fallot (c-ToF) and to investigate the relationships between LA function and patient characteristics, especially history of life-threatening arrhythmia (h-LTA).MethodsFifty-one c-ToF patients (34 males; age, 39 ± 15 years; h-LTA, n = 13) were included in this retrospective monocenter study. In addition to a 2D standard echocardiography examination, 2D strain analysis was performed to assess left ventricular (LV) and LA functions, including peak-positive LA strain (LAS—reservoir function) and LA compliance [defined as the ratio LAS/(E/Ea)].ResultsPatients with h-LTA were older and exhibited a longer QRS duration. LV ejection fraction, LAS and LA compliance were significantly lower in the group of patients with h-LTA. Indexed LA and RA volumes, RV end-diastolic area was significantly higher and RV fractional area change significantly lower in the h-LTA group. LA compliance was the best echocardiographic predictor for h-LTA (AUC: 0.839; p < 0.001). Moderate inverted correlations were found between LA compliance and age and QRS duration. Among the echocardiographic parameters, LA compliance was moderately inversely correlated with RV end-diastolic area (r = −0.40, p = 0.01).ConclusionWe documented abnormal LAS and LA compliance values in adult c-ToF patients. Further study is needed to determine how best to incorporate LA strain, particularly LA compliance, into multiparametric predictive models for LTA in c-ToF patients.

【 授权许可】

Unknown   
© 2023 Vautier, Mulet, Macquaire, Cousergue, André, Maragnes, Ollitrault and Labombarda.