Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy

Diabetology & Metabolic Syndrome

Review

Yang Xie¹  Guangjian Jiang²  Meng Huang²  Zhen Yang²  Hongbing Liu²  Xuehua Yan³  Dongqing An⁴ 

[1] Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University, Xinjiang, China;College of Traditional Chinese Medicine, Xinjiang Medical University, Xinjiang, China;College of Traditional Chinese Medicine, Xinjiang Medical University, Xinjiang, China;Xinjiang Key Laboratory of Famous Prescription and Science of Formulas, Xinjiang, China;College of Traditional Chinese Medicine, Xinjiang Medical University, Xinjiang, China;Xinjiang Key Laboratory of Famous Prescription and Science of Formulas, Xinjiang, China;Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University, Xinjiang, China;

关键词: Ferroptosis;    Lipid peroxidation;    Diabetic cardiomyopathy;    Diabetes;   

DOI  :  10.1186/s13098-023-01135-5

 received in 2023-04-11, accepted in 2023-07-09,  发布年份 2023

来源: Springer

【 摘 要 】

Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated to hypertension and coronary artery disease and can lead to heart insufficiency, heart failure and even death. Currently, the pathogenesis of DC is unclear, and clinical intervention is mainly symptomatic therapy and lacks effective intervention objectives. Iron overdose mediated cell death, also known as ferroptosis, is widely present in the physiological and pathological processes of diabetes and DC. Iron is a key trace element in the human body, regulating the metabolism of glucose and lipids, oxidative stress and inflammation, and other biological processes. Excessive iron accumulation can lead to the imbalance of the antioxidant system in DC and activate and aggravate pathological processes such as excessive autophagy and mitochondrial dysfunction, resulting in a chain reaction and accelerating myocardial and microvascular damage. In-depth understanding of the regulating mechanisms of iron metabolism and ferroptosis in cardiovascular vessels can help improve DC management. Therefore, in this review, we summarize the relationship between ferroptosis and the pathogenesis of DC, as well as potential intervention targets, and discuss and analyze the limitations and future development prospects of these targets.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 2