Exploring the diverse biomedical applications of programmable and multifunctional DNA nanomaterials

Journal of Nanobiotechnology

Review

Yumei Wang¹  Chen Shi²  Liuru Fang³  Zuzhao Xiong³  Yuhua Wang³ 

[1] Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China;Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China;Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, 430022, Wuhan, China;Hubei Province Key Laboratory of Systems Science in Metallurgical Process, Wuhan University of Science and Technology, 430081, Wuhan, China;

关键词: DNA nanomaterials;    Biological applications;    DNA self-assembly;    Tumors;   

DOI  :  10.1186/s12951-023-02071-2

 received in 2023-04-10, accepted in 2023-08-19,  发布年份 2023

来源: Springer

【 摘 要 】

DNA nanoparticles hold great promise for a range of biological applications, including the development of cutting-edge treatments and diagnostic tests. Their subnanometer-level addressability enables precise, specific modifications with a variety of chemical and biological entities, making them ideal as diagnostic instruments and carriers for targeted delivery. This paper focuses on the potential of DNA nanomaterials, which offer scalability, programmability, and functionality. For example, they can be engineered to provide highly specific biosensing and bioimaging capabilities and show promise as a platform for disease diagnosis and treatment. Successful operation of various biomedical nanomaterials has been demonstrated both in vitro and in vivo. However, there are still significant challenges to overcome, including the need to improve the scalability and reliability of the technology, and to ensure safety in clinical applications. We discuss these challenges and opportunities in detail and highlight the progress and prospects of DNA nanotechnology for biomedical applications.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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