A review on the effect of nanocomposite scaffolds reinforced with magnetic nanoparticles in osteogenesis and healing of bone injuries

Stem Cell Research & Therapy

Review

Hassan Dianat-Moghadam¹  Ahmad Mehdipour²  Azizeh Rahmani Del Bakhshayesh²  Daryush Mohammadnejad³  Hadi Sadeghzadeh⁴ 

[1] Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Anatomical Sciences, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran;

关键词: Nanocomposites;    Magnetic nanoparticles;    Scaffolds;    Bone;    Tissue engineering;   

DOI  :  10.1186/s13287-023-03426-0

 received in 2023-01-12, accepted in 2023-07-24,  发布年份 2023

来源: Springer

【 摘 要 】

Many problems related to disorders and defects of bone tissue caused by aging, diseases, and injuries have been solved by the multidisciplinary research field of regenerative medicine and tissue engineering. Numerous sciences, especially nanotechnology, along with tissue engineering, have greatly contributed to the repair and regeneration of tissues. Various studies have shown that the presence of magnetic nanoparticles (MNPs) in the structure of composite scaffolds increases their healing effect on bone defects. In addition, the induction of osteogenic differentiation of mesenchymal stem cells (MSCs) in the presence of these nanoparticles has been investigated and confirmed by various studies. Therefore, in the present article, the types of MNPs, their special properties, and their application in the healing of damaged bone tissue have been reviewed. Also, the molecular effects of MNPs on cell behavior, especially in osteogenesis, have been discussed. Finally, the present article includes the potential applications of MNP-containing nanocomposite scaffolds in bone lesions and injuries. In summary, this review article highlights nanocomposite scaffolds containing MNPs as a solution for treating bone defects in tissue engineering and regenerative medicine.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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