The mirror like expression of genes involved in the FOXO signaling pathway could be effective in the pathogenesis of human lymphotropic virus type 1 (HTLV-1) through disruption of the downstream pathways

BMC Research Notes

Research Note

Monireh Movahedi¹  Sahar Yaslianifard¹  Somayeh Yaslianifard²  Sayed‑Hamidreza Mozhgani³ 

[1] Department of Biochemistry, Faculty of Biological Sciences, NorthTehran Branch, Islamic Azad University, Tehran, Iran;Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran;Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran;Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran;Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;

关键词: Human T‑lymphotropic virus type 1;    Adult T‑cell leukemia/lymphoma;    HTLV‑1 associated myelopathy/tropical spastic paraparesis;    Pathogenesis;   

DOI  :  10.1186/s13104-023-06423-x

 received in 2022-10-28, accepted in 2023-07-04,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectivesHuman lymphotropic virus type 1 (HTLV-1) is the cause of two major diseases, ATLL and HAM/TSP in a percentage of carriers. Despite progress in understanding the pathogenesis of these two diseases, the exact pathogenesis mechanism is still not well understood. High-throughput technologies have revolutionized medical research. This study aims to investigate the mechanism of pathogenesis of these two diseases using the results of high-throughput analysis of microarray datasets.ResultsA total of 100 differentially expressed genes were found between ATLL and HAM/TSP. After constructing protein-protein network and further analyzing, proteins including ATM, CD8, CXCR4, PIK3R1 and CD2 were found as the hub ones between ATLL and HAM/TSP. Finding the modules of the subnetwork revealed the enrichment of two common pathways including FOXO signaling pathway and Cell cycle with two common genes including ATM and CDKN2D. Unlike ATLL, ATM gene had higher expressions in HAM/TSP patients. The expression of CDKN2D was increased in ATLL patients. The results of this study could be helpful for understanding the pathogenic mechanism of these two diseases in the same signaling pathways.

【 授权许可】

CC BY   
© The Author(s) 2023