Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma

Molecular Cancer

Review

Qingge Jia¹  Mingyang Li²  Lingbo An³ 

[1] Department of Reproductive Medicine, Xi’an International Medical Center Hospital, Northwest University, Xi’an, China;State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, China;State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, China;College of Medical Technology, Xi’an Medical University, Xi’an, China;

关键词: ESCC;    Cancer stem cells;    Radioresistance;    Molecular targets;    Reversal strategies;   

DOI  :  10.1186/s12943-023-01839-2

 received in 2023-04-13, accepted in 2023-08-02,  发布年份 2023

来源: Springer

【 摘 要 】

Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-related mortality worldwide, with more than half of them occurred in China. Radiotherapy (RT) has been widely used for treating ESCC. However, radiation-induced DNA damage response (DDR) can promote the release of cytokines and chemokines, and triggers inflammatory reactions and changes in the tumor microenvironment (TME), thereby inhibiting the immune function and causing the invasion and metastasis of ESCC. Radioresistance is the major cause of disease progression and mortality in cancer, and it is associated with heterogeneity. Therefore, a better understanding of the radioresistance mechanisms may generate more reversal strategies to improve the cure rates and survival periods of ESCC patients. We mainly summarized the possible mechanisms of radioresistance in order to reveal new targets for ESCC therapy. Then we summarized and compared the current strategies to reverse radioresistance.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 8