Cancer cells stemness: A doorstep to targeted therapy

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1866

Article

Prasad, Sandeo^1,2  Rarnachandran, Sharavan^1,2  Gupta, Nehal^1,2  Kaushik, Itishree^1,2  Srivastava, Sanjay K.^1,2 

[1] Texas Tech Univ, Hlth Sci Ctr, Dept Immunotherapeut & Biotechnol, Suite 1305,1718 Pine St, Abilene, TX 79601 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Ctr Tumor Immunol & Targeted Canc Therapy, Abilene, TX 79601 USA

关键词: Cancer stem cells;    Tumor relapse;    Chemoresistance;    Metastasis;    Molecular targets;   

DOI  :  10.1016/j.bbadis.2019.02.019

来源: Elsevier

【 摘 要 】

Recent advances in research on cancer have led to understand the pathogenesis of cancer and development of new anticancer drugs. Despite of these advancements, many tumors have been found to recur, undergo metastasis and develop resistance to therapy. Accumulated evidences suggest that small population of cancer cells known as cancer stem cells (CSC) are responsible for reconstitution and propagation of the disease. CSCs possess the ability to self-renew, differentiate and proliferate like normal stem cells. CSCs also appear to have resistance to anti-cancer therapies and subsequent relapse. The underlying sternness properties of the CSCs are reliant on multiple molecular targets such as signaling pathways, cell surface molecules, tumor microenvironment, apoptotic pathways, microRNA, stem cell differentiation, and drug resistance markers. Thus an effective therapeutic strategy relies on targeting CSCs to overcome the possible tumor relapse and chemoresistance. The targeted inhibition of these stem cell biomarkers is one of the promising approaches to eliminate cancer stemness. This review article summarizes possible targets of cancer cell stemness for the complete treatment of cancer.

【 授权许可】

Free