Breast conservation therapy decreased heart-specific mortality in breast cancer patients compared with mastectomy

BMC Surgery

Research

Ruipeng Zhao¹  Zhi Li¹ 

[1] Department of Thyroid and Breast Surgery, The Affiliated Huaian No People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, China;

关键词: Breast cancer;    Breast conservation therapy;    Mastectomy;    Cardiotoxicity;    SEER;   

DOI  :  10.1186/s12893-023-02132-1

 received in 2023-04-24, accepted in 2023-07-31,  发布年份 2023

来源: Springer

【 摘 要 】

AimTo investigate the impacts of breast conservation therapy (BCT) and mastectomy on heart-specific mortality in breast cancer patients.MethodsPatients with primary breast cancer registered in the Surveillance, Epidemiology, and End Results (SEER) database between Jan 1998 and Dec 2015 were included. Patients were divided into either breast conservation therapy or mastectomy group. To compare mortality caused by heart diseases in breast cancer patients with BCT or mastectomy, univariate and multivariate regression after propensity score matching (PSM) were performed. Kaplan-Meier analysis was also used to evaluate heart-specific survival between two groups.Results132,616 patients with breast cancer were enrolled in this study. After PSM, four risk factors including age, race, marital status and types of surgery were identified significantly associated with death from heart diseases. Heart-specific survival analysis further showed that overall, BCT poses a lower risk to heart-specific mortality compared with mastectomy.ConclusionCompared with mastectomy, BCT significantly decreased heart-specific mortality in breast cancer patients.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 7

Fig. 4

13570_2023_282_Article_IEq19.gif

13570_2023_282_Article_IEq9.gif