Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges

Military Medical Research

Review

Zhao-Yu Li¹  Gao-Feng Shu²  Jian-Song Ji²  Shi-Ji Fang²  Jia-Yi Ding³  Min-Jiang Chen³  Zhou-Guang Wang³  Xiao-Kun Li⁴  Ling-Feng Wu⁵  Xu-Ran Chu⁶ 

[1] Department of Overseas Education College, Jimei University, 361021, Xiamen, Fujian, China;Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Institute of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, 323000, Lishui, Zhejiang, China;Clinical College of the Affiliated Central Hospital, School of Medicine, Lishui University, 323000, Lishui, Zhejiang, China;Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Institute of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, 323000, Lishui, Zhejiang, China;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China;Clinical College of the Affiliated Central Hospital, School of Medicine, Lishui University, 323000, Lishui, Zhejiang, China;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China;Department of Medicine II, Internal Medicine, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392, Giessen, Germany;Pulmonary and Critical Care, Department of Medicine V, Internal Medicine, Infectious Diseases and Infection Control, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392, Giessen, Germany;

关键词: Mesenchymal stem cell (MSC);    Extracellular vesicles (EVs);    Wound repair;    Engineered nanoparticles;   

DOI  :  10.1186/s40779-023-00472-w

 received in 2023-02-08, accepted in 2023-07-24,  发布年份 2023

来源: Springer

【 摘 要 】

Skin wounds are characterized by injury to the skin due to trauma, tearing, cuts, or contusions. As such injuries are common to all human groups, they may at times represent a serious socioeconomic burden. Currently, increasing numbers of studies have focused on the role of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in skin wound repair. As a cell-free therapy, MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell therapy. Treatment based on MSC-derived EVs can significantly promote the repair of damaged substructures, including the regeneration of vessels, nerves, and hair follicles. In addition, MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization, wound angiogenesis, cell proliferation, and cell migration, and by inhibiting excessive extracellular matrix production. Additionally, these structures can serve as a scaffold for components used in wound repair, and they can be developed into bioengineered EVs to support trauma repair. Through the formulation of standardized culture, isolation, purification, and drug delivery strategies, exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound repair. In conclusion, MSC-derived EVs-based therapies have important application prospects in wound repair. Here we provide a comprehensive overview of their current status, application potential, and associated drawbacks.

【 授权许可】

CC BY   
© People´s Military Medical Press 2023

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