Interaction of engineered nanoparticles with toxic and essential elements

3rd International Youth Conference on Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology

物理学;医药卫生;生态环境科学

Shumakova, A.A.^1 ; Gmoshinski, I.V.^1 ; Khotimchenko, S.A.^1 ; Trushina, E.N.^1

Federal State Budgetary Science Institution, Institute of Nutrition, 2/14, Ust'inskiy proezd, Moscow

109240, Russia^1

关键词: Combined actions;    Dose dependences;    Engineered nanoparticles;    Essential elements;    Immune function;    Laboratory animals;    Natural environments;    Toxic trace elements;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/98/1/012043/pdf
DOI  :  10.1088/1757-899X/98/1/012043

来源: IOP

【 摘 要 】

Interaction of engineered nanoparticles with toxic and essential trace elements must be taken into consideration when estimating risks of NPs presented in the natural environment. The purpose of this work was to study the possible influence of silica, titanium dioxide (rutile) and fullerenol NPs on the toxicity of cadmium and to research the status of some trace elements and related indices of immune function in experiments on laboratory animals. Young Male Wistar rats received cadmium salt (1 mg/kg b.w. Cd) orally for 28 days separately or in conjunction with the said kinds of NPs in different doses. A number of effects was observed as a result of combined action of Cd together with NPs, increase in bioaccumulation of this toxic trace element in the liver was most evident. The observed effects didn't show simple dose- dependence in respect to nanomaterials that should be taken into consideration when assessing the possible risks of joint action of nanoparticles and toxic elements existing in the environment in extremely low doses. Violation of microelement homeostasis caused by the combined action of Cd and NPs can have various adverse effects, such as inhibition of T-cell immunity induced by co-administration of Cd with rutile NPs.