Association between cumulative atherogenic index of plasma exposure and risk of myocardial infarction in the general population

Cardiovascular Diabetology

Research

Shouling Wu¹  Shuohua Chen¹  Fen Liu²  Penglian Wang³  Qin Xu⁴  Anxin Wang⁴  Xue Xia⁴  Xiaoli Zhang⁴  Jing Li⁴  Yijun Zhang⁵  Xue Tian⁵ 

[1]Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China

[2]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You’anmen Wai, Fengtai District, 100069, Beijing, China

[3]Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China

[4]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S 4th Ring W Rd, Fengtai District, 100070, Beijing, China

[5]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

[6]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S 4th Ring W Rd, Fengtai District, 100070, Beijing, China

[7]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

[8]Department of Clinical Epidemiology and Clinical Trial, Capital Medical University, Beijing, China

[9]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S 4th Ring W Rd, Fengtai District, 100070, Beijing, China

[10]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

[11]Department of Clinical Epidemiology and Clinical Trial, Capital Medical University, Beijing, China

[12]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You’anmen Wai, Fengtai District, 100069, Beijing, China

[13]Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China

关键词: Time course;    Cumulative exposure;    Atherogenic index of plasma;    Myocardial infarction;   

DOI  :  10.1186/s12933-023-01936-y

 received in 2023-06-06, accepted in 2023-07-22,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAtherogenic index of plasma (AIP) has been confirmed as a novel marker for myocardial infarction (MI), but few evidence on the long-term AIP and MI risk in general populations. We thus aimed to evaluate the relationships of cumulative exposure to AIP and its accumulation time course with the risk of MI.MethodsA total of 54,440 participants were enrolled in the Kailuan study. Time-weighted cumulative AIP was calculated as the weighted sum of the mean AIP value for each time interval, then normalized by total exposure duration, the exposure duration was from 2006 to 2010. Duration of high AIP exposure was defined as the duration with high AIP and ranged from 0 to 6 years. The time course of AIP accumulation was categorized by the combination of time-weighted cumulative AIP < or ≥ median (− 0.12) and AIP slope.ResultsAfter 11.05 years of follow-up, 766 incident MI cases were documented. After adjustment for potential confounders, higher risk of MI was observed in participants with the highest time-weighted cumulative AIP quartile (HR, 1.89; 95% CI 1.47–2.43), the longest exposure duration of high AIP (HR, 1.52; 95% CI 1.18–1.95), and those with high time-weighted cumulative AIP and negative slope (HR, 1.42; 95% CI 1.13–1.79).ConclusionsLong-term cumulative exposure to AIP and the time course of AIP accumulation increased the risk of MI. High AIP earlier resulted in a greater risk increase than later in life with the same time-weighted cumulative AIP, emphasizing the importance of controlling atherogenic dyslipidemia early in life.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 1