Interleukin-5 levels in relation to malaria severity: a systematic review

Malaria Journal

Research

Nsoh Godwin Anabire¹  Chusana Mekhora²  Aongart Mahittikorn³  Thitinat Duangchan⁴  Kwuntida Uthaisar Kotepui⁴  Manas Kotepui⁴ 

[1] Department of Biochemistry & Molecular Medicine, School of Medicine, University for Development Studies, Tamale, Ghana;Department of Biochemistry, Cell & Molecular Biology, West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana;Department of Nutrition and Health, Institute of Food Research and Product Development, Kasetsart University, Bangkok, Thailand;Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;Medical Technology Program, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand;

关键词: Malaria;    Severe;    Uncomplicated;    Complicated;    IL-5;    Interleukin;    Cytokine;   

DOI  :  10.1186/s12936-023-04659-3

 received in 2023-01-15, accepted in 2023-07-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe role of cytokines such as interleukin-5 (IL-5) in the pathogenesis of malaria remains unclear. This systematic review sought to synthesize variations in IL-5 levels between severe and uncomplicated malaria, as well as between malaria and controls not afflicted with the disease.MethodsThis systematic review was registered at the International Prospective Register of Systematic Reviews (PROSPERO; CRD42022368773). Searches for studies that reported IL-5 levels in patients with malaria (any severity) and/or uninfected individuals were performed in Web of Science, PubMed, EMBASE, Scopus, CENTRAL, and MEDLINE, between 1st and 10th October, 2022. The risk of bias among all included studies was minimized using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for reporting observational studies. The differences in IL-5 levels between malaria and uninfected controls, and between severe and uncomplicated malaria were synthesized by narrative synthesis.ResultsAmong 1177 articles identified in the databases, 23 matched the eligibility criteria and were included in this systematic review. Qualitative syntheses showed the heterogeneity of IL-5 levels between different severities of clinical malaria and uninfected controls. The majority of the included studies (12/15 studies, 80%) found no change in IL-5 levels between malaria cases and uninfected controls. Similarly, most studies found no difference in IL-5 levels between severe (regardless of complications) and uncomplicated malaria (4/8 studies, 50%). The qualitative syntheses revealed that most studies found no difference in IL-5 levels between severe and non-severe malaria.ConclusionsThe comprehensive review suggests that IL-5 levels are unchanged in patients with different levels of clinical severity of malaria and uninfected controls. Given the limited number of published studies on IL-5 levels in malaria, there is a need for additional research to determine the function of this cytokine in the pathogenesis of malaria.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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